Endocrine Abstracts

Background: Neurotrophins are implicated in the physiology and pathophysiology of the mature gastrointestinal tract (GIT) such as motility and inflammatory bowel disease. Moreover, GIT disturbances has been attributed to hyperinsuliemia. Insulin-neurotrophins interactions in the (GIT) have not been investigated yet.Aim: To test the effect of Insulin on the expression of neurotrophins in the muscular wall of mice intestine and colon.<p class="abstext"...

Lipid peroxidation is linked with several metabolic diseases. Lipid peroxidation causes cellular damage through reactive aldehyde species such as 4-hydroxyonenal (4-HNE). The exact mechanism(s) by which 4-HNE causes damage in the intravascular compartment is not exactly known. Using an in vitro system, we investigated the damage induced by 4-HNE on the blood by measuring protein carbonyl groups and thiobarbituric acid reactive substances (TBARS) following 4-HNE treatm...